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Masters and Libby compile study information for hospital-wide presentation; DePaul and Johnson travel to a medical convention; Virginia's ex returns finds Ethan playing father to his children.
A former study participant comes forward with news of her pregnancy. Ethan learns he has been effectively fired, but not for the reason he thought.
Dr. Masters' big day is at hand after 12 months of studies. Without Virginia as a voice of moderation will Bill's pitch hit the mark? Margaret Scully is confronted with her husbands homosexuality and investigates what is involved with his 'treatment'. Dr. Austin Langham has a job offer from L.A and the climax to the episode sees Virginia Johnson reading the notes from Dr. William Masters presentation at home in the rain, to hear a knock at the door.
Former singer and single mother Virginia Johnson becomes the assistant to renowned OBGYN William Masters. They embark on their pioneering study in human sexuality while trying to navigate their personal feelings for each other.