The seventies are in full swing and sexual experimentation is all the rage. Masters and Johnson should be celebrating, but their clinic is in legal trouble, their personal lives are in tatters and their relationship is on the rocks.

Thrust into the spotlight by the publication of their controversial study, Dr. William Masters and Virginia Johnson find themselves the unlikely leaders of the sexual revolution.

Dr. William Masters and Virginia Johnson struggle to get their work back on track while taking their relationship to a much more intimate place; Libby flounders in a loveless marriage and turns to volunteering.