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The study costs Masters his obstetrics and gynaecology practice. Johnson struggles with DePaul.
Johnson tries to cover when she and Masters are seen by Langham leaving a hotel together after an evening tryst. Later, Masters attempts to bring Johnson aboard as his assistant at his new post; and Betty tries to conceal her infertility from Gene, over Masters' objections.
After Hendricks bans Masters from using black participants in his study, Masters contacts a journalist to promote his efforts, using the debunking of sexual stereotypes as the lure. Johnson is forced to accept DePaul's choice to end her chemotherapy treatments. Gene uncovers the truth about Betty and Helen's relationship. Libby fires Coral after discovering she lied about Robert.
Dr. William Masters and Virginia Johnson struggle to get their work back on track while taking their relationship to a much more intimate place; Libby flounders in a loveless marriage and turns to volunteering.