Will begins to experience strange visions that are connected to the Cult of Kali. Magnus has difficulty with finding the solution to their problems.

The team investigate a murder in Mumbai, and find a connection to the ancient cult of Kali, whose followers can foretell disaster. However, Will falls ill and disappears, and is somehow linked to the mystery.

The team rescues the occupants of a sinking ship off the coast of South Africa and teleport them to the Sanctuary. However, Magnus suspects Druitt of murdering one of the passengers during the rescue.

Magnus and Will investigate a number of inexplicable teenage disappearances. The common denominator in the case seems to be that they all recently spent time at an exclusive rehab clinic in Mexico.

Magnus is reunited with an old friend, Jimmy who is transporting a valuable elemental Abnormal to the Sanctuary for safety. But an underground mob accustomed to cashing in on the Abnormal black market, tracks down Jimmy and his valuable cargo before the delivery is complete. Magnus and Jimmy find themselves in a dangerous shootout, determined to save the Abnormal.

Magnus and Will are called to make a straightforward retrieval of a rare Abnormal off the coast of Louisiana. With a commissioned helicopter, the retrieval is successful and their cargo securely on board. But as the pair starts heading back to the mainland, something causes the unusual sea creature to break loose.

Will goes up against the heads of the Sanctuary Network to defend Magnus who is charged with a shocking murder. But as the evidence stacks up against her, even Will has trouble finding a way to convincingly defend her innocence.

Dr. Helen Magnus fights to save the life of one of the Sanctuary's research scientists who was viciously attacked by a seemingly docile Abnormal. Baffled by the creature's uncharacteristic behavior, Henry tries to figure out what, or who, caused the domesticated Abnormal to react so violently.

A disoriented Magnus wakes up to find the Sanctuary in ruins and the entire city decimated, with no memory of how the devastation occurred.

A superhero is trapped by Magnus, and his lack of finesse affects the team's work. Elsewhere, Will and Declan go on the search for a creature that's loose in the city, after the discovery of an eggshell.

With chaos all around them, the team must come to terms with how to rebuild after the Cabal's attacks. Magnus takes a methodical approach to prove Ashley is still alive, while Will and Henry take on the daunting task of processing the hundreds of Abnormals who now seek refuge at the Sanctuary.

Furious at being duped into a trap, Magnus takes on Kate, demanding information and complete access to her Cabal contacts. The Cabal's true agenda is revealed and Magnus realizes that they are not only holding Ashley as ransom to obtain complete control of the Sanctuary Network, but turning her into the ultimate weapon. She might have to choose between saving her only daughter, or losing the Sanctuary and all the lives and secrets within it.

The search for Ashley puts Magnus and her allies in the path of Kate Freelander (Agam Darshi), a con artist with ties to the Cabal who divulges the location of a secret facility.