After Joker "steals" one of her heists, Harley figures that she needs to put together a crew of her own. However, no man wants to work for a female super-villain.

Harley is forced to make a decision on her own and suffers level-four brain freeze. To save her, Dr. Psycho takes the crew into Harley's mind to reboot it. Meanwhile Sy teams up with his old spy partner to dispose of the comatose crew members.