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Harley has her final showdown with the Joker, when [spoilers] [spoil] [spoilers]. Will they [spoiler]? Maybe. But you can bet they [spoiler]!
Harley thinks the Legion of Doom is behind Ivy's capture and the tree monsters currently ravaging Gotham. But it's a trap!
Harley must rescue Ivy from the clutches of Scarecrow, who's trying to harvest her pheromones to make a super toxin that turns plants into sentient monsters.
After a falling out with her crew, Harley heads back home to Bensonhurst, where her doting mother waits for her... and her deadbeat dad, who's more dangerous than anticipated.
Now a member of the Legion of Doom and The Joker's equal, Harley finds herself spending time with him. Will she slip into her old ways?
Harley gets an invite to the Legion of Doom's prospective members party, but Ivy discovers that it's her they're really after.
Harley breaks the Queen of Fables out of prison to add some evil oomph to her crew – but maybe Fables is a little TOO evil?
Commissioner Gordon loses a friend in Batman, but gains a new one when he interrogates Clayface's severed arm. Meanwhile, Harley and Clayface try to steal the arm back, and Psycho and Ivy visits the Cowled Critic who dared to criticize Harley's crew.
Harley is forced to make a decision on her own and suffers level-four brain freeze. To save her, Dr. Psycho takes the crew into Harley's mind to reboot it. Meanwhile Sy teams up with his old spy partner to dispose of the comatose crew members.
When Harley tries to get her first nemesis, she ends up with Robin and isn't happy. Batman comes to his ward's rescue, and Joker comes looking for the nemesis that he thinks Harley stole from him.
After Joker "steals" one of her heists, Harley figures that she needs to put together a crew of her own. However, no man wants to work for a female super-villain.
Harley crashes Penguin's nephew's bar mitzvah in an attempt to impress the Legion of Doom. Kite Man hits on Ivy, and Joker can't resist demeaning Bane.
Joker abandons Harley Quinn--again--and Poison Ivy tries to convince Harley that Joker is no good for her.
The fifth season of Harley Quinn finds Harley (Kaley Cuoco) and Ivy (Lake Bell) in a new location: Metropolis! – the home of all things Superman, Lois Lane, and the Daily Planet. Harley and Ivy discover that something sinister is at play and all is not what it seems. Looming threats include Lex Luthor and his sister, Lena Luthor, plus fan-favorite Brainiac. But of course, Harley's crew of misfits and allies will join her on this irreverent journey that takes no prisoners in having fun in the DC sandbox.