When Gus intensifies efforts to persuade Walt to get back in the meth business, Jesse takes exception and a rift appears in his and Walt's personal relationship. Meanwhile, Skyler's new relationship isn't turning out as she'd like; and Marie tells Skyler about her concerns for the increasingly troubled Hank and his well-being.

Hank's behavior becomes increasingly more unpredictable and volatile, which leads to a confrontation with Jesse and problems at the DEA; Skyler wants Walt to make a deal; and Gus' decisions result in some serious consequences.