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The planned kidnapping of King Francis goes awry but Catherine devises a new plan to allow her control of the country.
Mary visits Rahima and recounts her side of the story of life at the Royal Court. Catherine and Mary have conflicting views when it comes to freedom of religion in France.
Catherine has a dream that predicts that her husband will be wounded while jousting. Catherine and Henri decide that their son Francis should delay his wedding to Mary.
King Henri departs to lead an army to defend France and places Catherine in charge as Regent, allowing her to test her powers further. Catherine asks Rahima to search Mary's room for a letter.
Catherine has become a mother. King Francis suffers a fall from his horse while hunting with Henri and Catherine.
Prince Henri returns from war with a new mistress, Filippa, and a baby. Catherine resorts to extreme measures to produce an heir.
Young Catherine begins to learn how to outwit the royal household in order to secure her future.
Queen Catherine confides in a servant girl and begins to tell the story of her life, including the circumstances surrounding her arrival at the French Royal Court at the age of 14.
In season two, Catherine de Medici is Queen Regent of France now that her son, Charles IX has come of age. Distracted by the personal conflicts of the Valois children, a new mysterious prophet named Edith gains a loyal following who vow to challenge the current religious establishment, sparking tension across the country. Feeling threatened by the rising strain, the divided court turn to their own schemes for selfish benefit. The Guises commit unholy acts while the Bourbons turn to a familiar foreign sovereign, Queen Elizabeth I of England in hopes of personal gain. As France falls into political and religious turmoil, Catherine struggles to maintain her power, but The Serpent Queen will do whatever she needs to regain control.