Anarchic comedian Johnny Vegas and broadcaster Alex Brooker embark on a road trip to explore their family histories. Alex knows nothing about his family history, and is blown away to find a relative who met Jack the Ripper. Meanwhile, Johnny is aware that generations of his family have worked in St Helens, and is fascinated to learn of the ancestor who moved his family northwards through the booming industry of glassblowing.

Oti and Motsi Mabuse head on a journey across their homeland of South Africa to explore their extraordinary family history. The sisters have tried to explore their history before, but with records for black South Africans almost nonexistent, going on their DNA journey is the last roll of the dice to discover their roots.