Alex treats a young boy with mysterious symptoms while dealing with the arrival of Charlie's ex-wife. Elsewhere in the hospital, Joel and Maggie try to help a patient who refuses life-saving treatment on religious grounds.

A sleep-deprived Alex takes on a night shift in the ER where an all-star hockey enforcer may be skating full-speed towards an early death. Meanwhile, Charlie meets a suburban punk who is facing the biggest fight of his life.