When Alex's brother Luke is admitted to Hope Zion Hospital in critical condition, Joel and Charlie must work together to keep him alive while keeping his admittance a secret from Alex. Meanwhile, Alex figures out a way to remove a tumour from a patient pregnant with twins, while Maggie is thrown off her game by the patient's gorgeous OB/GYN.

When one of the doctors at Hope Zion Hospital life is at risk, Alex has to put her personal and professional issues aside. Charlie has to deal with the ghost of a ballerina.