Dawn diagnoses Alex with an irregular heartbeat. The Great Randall returns to Hope Zion Hospital after an experimental cancer treatment goes wrong. Meanwhile, Charlie struggles with the implications of his fight with Joel, who is trying to treat a troubled mathematician. One of Hope Zion's staff is attacked and their life is left hanging in the balance.

Alex struggles to help an older woman who starts to believe the year is 1985. Meanwhile, Charlie and Joel are pitted against one another by two best friends with identical shoulder injuries.

Alex races to find an organ replacement, while Charlie is pushed to his breaking point.

A couple is attacked by a bear, but Alex and Charlie think there's more to the story.

As Alex leaves Hope Zion she becomes a witness to an accident that brings her back to the hospital.

Alex's been tricked into a blind double date, and ends up rushing her mystery man to the ER. Charlie struggles with a spirit in the middle of a soldier's life-or-death surgery.

When one of the doctors at Hope Zion Hospital life is at risk, Alex has to put her personal and professional issues aside. Charlie has to deal with the ghost of a ballerina.

Alex risks a dangerous surgery on a seemingly inoperable tumor to save a young boy's life. Meanwhile, Joel struggles with the challenges of being Chief of Surgery as Charlie struggles with the spirit of Alex's dead brother Luke.

When Alex's brother Luke is admitted to Hope Zion Hospital in critical condition, Joel and Charlie must work together to keep him alive while keeping his admittance a secret from Alex. Meanwhile, Alex figures out a way to remove a tumour from a patient pregnant with twins, while Maggie is thrown off her game by the patient's gorgeous OB/GYN.

When Alex is forced to put a patient's gender reassignment surgery on hold, she discovers a secret in his medical history that could save his surgery, but tear his life apart. Charlie deals with a patient who is healthy, sane - and convinced she is going to die at midnight. Meanwhile, Joel secretly helps Sonja deal with a patient of hers who's been admitted to Hope Zion Hospital.

When Alex and Joel end up stranded in the middle of nowhere with a severely injured couple, they're forced to use only what's around them to stabilize the pair until paramedics arrive. Meanwhile, back at Hope Zion Hospital, Charlie must try to save the wounded leg of his former college roommate as Gavin attempts to help Shahir improve his bedside manner.

When a heat wave hits the city, Alex is appointed Trauma Team Leader as the hospital is faced with an influx of patients during a blackout. With no back-up power available, Dawn and Charlie must figure out a way to continue their surgery as Joel and Maggie attempt to keep a patient alive while stuck in an elevator.

After a young, healthy, and hunky fireman dies suddenly at Hope Zion, Alex must take the stand at M&M (Morbidity and Mortality) Rounds to find out what went wrong and who is to blame. Meanwhile, Charlie deals with a nervous soon-to-be Nun and Joel has to decide if he can be the man that comes through for Sonja.

Alex must become the unlikely advocate for a violent young prisoner brought in to Hope Zion, while Joel connects with a disfigured refugee and tries to convince Dana Kinney to come back to operate on him. Meanwhile, a Spirit who is familiar to many Hope Zee doctors shows up in the Morgue when Charlie is about to do routine procedure.

The doctors are forced to deal with people from their past as Alex, Charlie, and Joel take on the daunting task of operating on a malpractice lawyer known for suing every doctor in his path.

While struggling under the pressure of deciding on her specialty, Alex is inspired by an immigrant doctor who needs her help to save his wife.

Alex learns to stand up to Charlie's ex-wife Dawn.

Charlie returns to Hope Zion for his first shift as a doctor since waking from the coma and is surprised that he can still see the spirits of people who died at the hospital.