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Alex must maintain her professionalism when Kristine lands at Hope Zion Hospital after a drunk-driving accident with baby Luke's blanket.
With Dana back from Paris, Alex enlists her help to save Lorenzo, a hot-tempered chef suffering from oral cancer. Her concerns over her friend's own treatment (or lack there-of) quickly bubble to surface however, when their patient refuses medical attention in favour of pursuing the opening of his restaurant. Meanwhile, Charlie has his hands full juggling the spirit of a restless single mother, while working to save her life after a DIY treehouse accident.
Alex and Jeremy struggle to find the truth when all the symptoms of a permanently ill child point towards his mother as the cause.