West Virginia pharmacist Natalie Cochran is left widowed after her 38-year-old husband Michael suddenly dies. Their closeknit neighborhood rallies around Natalie and her two young children until troubling details emerge regarding the couple's new business venture.

Jasmine "Jazzy" Pace mysteriously vanishes, missing her family's Thanksgiving dinner. Determined to track her down, her family takes matters into their own hands, pursuing every digital clue she left behind. 

A girl returns home from school to find her father, celebrity hairdresser Fabio Sementilli, brutally murdered in their backyard. A neighbor's security camera helps investigators identify unlikely suspects as the murder captivates not just Hollywood, but the country. 

A college student home for the summer goes missing while jogging; her closeknit Iowa town comes together to search for her until investigators discover security camera video that reveals a critical clue. 

Kansas couple Mike Sisco and Karen Harkness are found dead by their parents before a family fish fry in 2002. A years-long search for evidence and three criminal trials over two decades reveal strained dynamics within one victim's family.

INTERVIEWS WITH: Mike Sisco's mother Carol Sisco, daughter Hailey Seel, sister Cathy Boots and brother-in-law Mark Boots; Karen Harkness' daughter Erin Harkness Sutton and son Chad Harkness; Fmr. Topeka police Sgt. Richard Volle; Shawnee County District Attorney Mike Kagay; and others.

The unexplained death of a beloved chiropractor becomes a criminal investigation when authorities discover she'd been poisoned; nearly a decade after the murder, a court makes a dramatic decision about the young woman at the heart of the case.

A middle school art teacher is shot to death in the home she shared with her husband; new evidence and testimonies poke holes in the story of a harmonious three-way affair between the couple and a mutual friend. 

In her first TV interview, convicted murderer Lori Vallow Daybell speaks to Dateline correspondent Keith Morrison. In the exclusive sit down, Lori maintains her innocence after she and her husband Chad Daybell were found guilty of murdering her children, JJ and Tylee. Chad was also found guilty of murder and conspiracy in the death of his previous wife Tammy and Lori was found guilty of conspiring to kill Tammy.

After 25-year-old Chantay Blankinship's remains are found at an abandoned building that locals call the Haunted House, investigators sort through dead-end leads until a stunning confession during a church service changes everything.

The murders of teenagers Abby and Libby in their close-knit hometown of Delphi, Indiana spark worldwide headlines. The high-profile case takes a stunning twist after detectives reveal Libby captured a video of the killer shortly before her death - a crucial piece of evidence that helps police track down the murderer. During the two-hour Dateline, correspondent Andrea Canning speaks with insiders in the case, including the defense attorneys for the killer.

Return to the Lake, provides an exclusive inside look at the case that riveted the country, through in-depth interviews with Susan Smith's defense attorney, David's current wife, and the Chief of SLED, as well as rarely heard interrogation audio of Susan from the initial investigation. Friday's broadcast is a continuation of Dateline's decades-long reporting on Smith, who recently was denied parole in November. 

During "Under the Bay Bridge," San Francisco Police Sergeant Brent Dittmer reveals that his team chose not to publicly dispute any theories that Lee was a victim of a robbery,  even though he believed early on that the person responsible for Lee's murder wasn't after his money. He tells Mankiewicz, "If that's the story people are gonna run with, that is an advantage for us because the people who are responsible, we don't want to know what we know." He continued, "Let everybody think that this is whatever's on Twitter at that time. We'll work on what actually happened."

 Lee's former wife also had a hard time believing he was robbed, explaining, "Had Bob been approached by someone that was trying to mug him, he would've given him, them, the shirt off his back, his wallet, his keys, his clothes. He would've said, ‘Hey, man, let me buy you a meal. Please don't hurt me.'"

An elderly socialite is reported missing from her stately New York City brownstone. When Sante Kimes and her son Kenny are arrested, an investigation reveals decades of crime, deception and murder that captivated the nation.   

INTERVIEWS WITH: Kenny Kimes, Kenny's half-brother Kent Walker, Kent's high school girlfriend Rhonda Martin, Detectives Thomas Hovagim, Bill Cox, and Ed Murray, Private Investigator John Doty, TV Producer Maria Zone, Ken Holmgren, son of Sante Kimes' suspected murder victims

When young father Rob Limon is murdered at work, the investigation uncovers deep secrets about sex, friendship, religion and family. Sunday's broadcast explores the twisted case featured in Dateline's #1 podcast, Deadly Mirage.

After Gary "Big Daddy" Farris mysteriously disappears, his family discovers his remains on their sprawling 10-acre estate. An investigation reveals a family deeply divided by jealousy and greed, but did one of them kill Big Daddy?