We meet with famed LSD chemist Casey Hardison in the Nevada desert and embark on a road trip to visit an unsung hero of psychedelic history--Darrell Lemaire.

Hamilton embarks on an aquatic adventure to Reunion Island and Madagascar to investigate icthyoallyeinotoxism and a twisted history of hallucinogenic fish.

From the Aztec empire to the underground laboratory, Hamilton explores magic mushrooms with the help of shamans, clandestine growers, and ethnomycologists.

From the heavenly cloud forests of Oaxaca to a viral video of Miley Cyrus, Hamilton investigates the inconspicuous yet extraordinary psychedelic plant Salvia divinorum.

Hamilton travels across the USA meeting with addicts, dealers, and chemists to trace the history of PCP from its pharmaceutical origins to its escape onto the streets.

South Africa is the last place on earth Quaaludes can still be found. Hamilton travels there to study the drug and finds a dark history of medical experimentation.