Host Cat Deely welcomes people who make a commitment to complete a life changing, yearlong goal whose results the audience will see instantly. An adopted man searching for his biological family, a woman yearning to lose 60 pounds, a couple who has struggled with fertility issues hoping to have a baby, a formerly obese young woman who wants to have the excess skin from her weight loss removed, and a lifelong stutterer who wants to overcome her affliction and perform stand-up comedy while her ailing mother can still watch her.

A woman with an amputated foot pledges to complete a triathlon; an obese woman wants to lose 100 pounds and wear a bikini for the first time; a blind girl yearns for a guide dog to help her navigate the world.