The invention of the luxury resort casino helps birth Sin City; a Harlem woman goes to war for what will become the state lottery system; an alluring magazine like no other is launched; and one of the most famous cigarette brands in history is created.

One of the richest men in the world may lose his tobacco empire; alcohol titans fight for their lives against the growing threat of Prohibition; New York City becomes ground zero in the battle to legalize contraception.

Jack Daniel pioneers American whiskey; Adolphus Busch creates an iconic beer; Buck Duke innovates the modern cigarette; Julius Schmid skirts the law selling his new condoms… all while the temperance movement rises to battle against them.