The RNLI volunteers race to try and rescue a teenager being swept out to sea on an inflatable, two girls caught in a rip current and a woman who has fallen from a cliff in Cornwall.

As storm Ophelia hits the British Isles, on the south-east coast of Ireland the Rosslare crew try to rescue a small yacht with three people on board. In Devon, the crew at Appledore race an incoming tide to try and reach a man stuck fast in quicksand, while on the north coast of Cornwall the crew of St Agnes must battle through huge breaking waves to reach two young boys being swept out to sea in a deadly rip current.

Police officer Vinny finds himself heading out into the darkness to try and rescue two teenage boys.

In Brighton the crew are called out to what they think is just a routine job - towing a yacht that has lost power back to harbour - but a sudden spring squall and mountainous waves leave the crew fighting to save the yacht and themselves from being dashed on the shore. Off the east coast of Ireland, the crew of the small fishing village of Howth respond to an emergency call from a family on a local beach - a teenage girl out on a sailing dinghy has capsized and is now being swept out into the Irish Sea. While on the island of Anglesey, the crew of Moelfre are also heading out to help a family in trouble - two women have swum out to save a friend's young son being blown out to sea on an inflatable, but it quickly becomes the rescuers that need saving themselves.

Keeping watch over the River Thames, the crew at Tower in central London, the busiest of the RNLI's 238 stations, are called to a man reported in the water eight miles downstream. On arrival, they discover a river bus already on the scene and their crew desperately trying to hang on to the unmoving man before he disappears under the water. At one of the most remote stations, Trearddur Bay on Anglesey, the crew are called to an inaccessible coastal fishing spot, where an angler has plunged face first down a cliff onto rocks. With no helicopter available, the crew and their small inshore lifeboat are the only option to get him to urgent medical treatment. While in Portsmouth, gale force winds and a churning sea make a routine rescue particularly challenging.

From first timers at sea to salty old skippers, the wrong conditions can catch anyone off their guard leaving them in need of rescuing. On the east coast of Ireland, the crew of Courtown's inshore lifeboat face one of their most challenging shouts ever - in deep water they must keep a teenage girl with suspected spinal injuries immobile and afloat for 40 minutes, knowing any movement could leave her paralysed for life. Meanwhile on the English Riviera in Devon, the Torbay crew have just minutes to find a capsized kayaker before she is dashed against the rocks, and in Dartmouth, an 81-year-old sailor, fallen overboard in the middle of the night, is left clinging to a rope for his life.

Out at sea, minutes and even seconds can make the difference between life and death. On the south coast of Devon, the crew of Salcombe lifeboat station are called to two of the highest level of emergencies at sea - a mayday call to a fisherman pulled to the bottom of the sea ensnared in his own fishing gear and a devastating fire on a boat 15 miles out in the Channel. Over 200 miles away in the waters off Anglesey, as they go to the rescue of a father and his 13-year-old son missing at sea, the crew of Moelfre station uncover a story of survival and heroism.