The second season picks up where the first left off, with Dr Susannah Newman now on a desperate quest to track down a self-confessed serial killer before he kills again that night. When a mysterious new client Jon admits under hypnosis that he is a murderer and intends on killing another young female that evening, Susannah knows he must be stopped at all costs.

When he escapes before the police arrive and as her former lover Detective Superintendent Richard Grove is refusing to take action, Susannah is forced to embark on her own deadly mission to save Sapphire's life, the way she couldn't do with her own daughter.