During a near-death experience, a man becomes possessed by an evil entity which calls itself Roger and has some unfinished business at All Souls.

Five female athletes arrive for treatment at the All Souls Sports Medicine Clinic only to start dying one by one for no discernible reason.

A doctor carrying a deadly diseased is admitted to the hospital for treatment at the same time as what seems to be his doppelganger.

A teenager is admitted to All Souls' psychiatric ward and someone wants him to stay there.

When Mitchell's friend, Patrick Fortado, is left paralyzed after being hit by a car, Mitchell's colleague, Dr. Stefani Volette, agrees to treat him, but a price must be paid for her special treatment to work.

After graduating from medical school, Dr. Mitchell Grace joins the staff of All Souls, a Boston teaching hospital rumored to be haunted, and faces his first challenge.