Mike visits with long-time fans Marilyn and Carolyn Maedel to look at never-before-seen footage at a crawfish factory in Louisiana. Then, he experiences the many hands-on duties that come with being a termite researcher on Sapolo Island in Georgia.

Mike works on a fish processing boat in the Bering Sea and cleans out the fish grinder. Then he heads to the Rapid River Rustic Mill to lend a hand with debarking, peeling and processing wood for a cedar log cabin.

Mike heads to Tarpon Springs, Florida to help collect sponges off the sea floor. Then he answers viewer mail and recounts his struggle with a metal fence post at an abandoned mine.

Mike visits a jelly bean company to create a flavored jelly bean based on the smell of his boots; he then travels to Maine to harvest blueberries, before joining in a pie bakeoff.

Mike learns how to make a pig delicacy known as scrapple and later becomes a shoe doctor's assistant. 

Mike installs a metal power pole in Wyoming and later learns about how to remove lice from hair in San Francisco. 

Mike visits a distillery, where he turns molasses into rum, hauls hoses, scours copper and works with scalding liquid.

In Nebraska, Mike Rowe takes a shot at paving roads. Then, in reply to a mailbag question about his favorite animal, he recalls the time he crossed paths with a tiger crossbreed in Texas.

Mike Rowe climbs date palms with the pollinators guaranteeing a good crop of fruit, cuts granite, and tries his luck at the gun range; he also answers viewer mail.

Mike heads to a San Francisco dump to learn how hawks are employed as a seagull-removing method; then he is off to work on a mobile meat processing truck.

Joe Pagan of the Kentucky Equine Research facility in Woodford County, Kentucky gives Mike the low-down on their work testing foods and training techniques in order to create healthier, more athletic horses.

Mike visits a bowling center in Fremont, Cal. and at the request of a fan turns the spotlight on his cameraman.

Mike spends a day working at Ohio Valley Natural Fibers, where he makes yarn from fleece; then he goes to work at a day spa in Michigan, where he helps wax hair.

Mike visits a forensic entomology lab where he helps inspect pig carcasses for maggots and other insects.

Mike learns how to install a lightning rod on a home in Lucedale, Miss.

Mike visits an old-fashioned corn mill in De Kalb, Miss. Also, Mike helps relocate a pair of exotic deer in Wills Point, Texas.

Mike helps the U.S. Fish and Wildlife Service in battling the sea lamprey population that threatens the fishing industry of the Great Lakes. Also, Mike makes meat gel to feed fish in Mandalay Bay Hotel and Casino's shark reef aquarium.

Mike acts as a fugitive attempting to outsmart a team of bloodhounds and evade being captured; combating invasive species in the Florida Everglades

Mike visits a Texas ranch that breeds exotic animals like sloths, lemurs, camels, and bearcats.