After Peter turns down on offer to turn a blind eye on Mr. Lincoln's crimes, the black goo alien and Eddie eagerly accept, including their 'test': defeat Spiderman! Now aunt May is recovering after a cardiac crisis, Peter feels even more guilty for neglecting his family and friends, who now forgive and support him. Only vindictive Eddie turns on his loved-ones.

Peter realizes he's completely neglecting his friends, influenced by the alien goo 'symbion'. As it hates vibrations, he tries to get rid of it exposing it to church bells, but it pins him down and evokes memories of how it all started, the trauma of Uncle Ben's murder. However Ben's memory stays and encourages Peter to resist and wrestle loose. Now he brings the goo back to the lab and thinks he freezes it to death. Eddie is furious his rehabilitation is turned to hopeless. But the symbiont survived, transfers to Eddie and brings Peter's memories along.

Peter was looking forward to a lazy Saturday, but Adrian Toomes manages to free from jail fellow criminal freaks Rhino, Electro, Sandman, Hammerhead and Doctor Octopus. At least the alien goo proves a very practical costume improvement. Yet it come at a price: amnesia, or the suit operates on its own. Meanwhile Pete is ostracized at school for 'selfishly' photographing Spidey instead of preventing the theft.

The Chameleon is out to blacken Spider-Man's name. The master of disguise loots the city while borrowing Spidey's look, forcing Peter Parker to get help from Black Cat.

While Colonel John Jameson struggles to land his damaged space shuttle, Spider-Man struggles to defeat the Green Goblin, who also threatens Hammerhead and Tombstone.

Tired of constantly being pushed around by others, the timid Otto Octavius has his robotic arms permanently attached to his back and becomes the deadly Doctor Octopus.

Peter Parker and Mary Jane Watson go to the Midtown High Fall Formal. Meanwhile, the mysterious Green Goblin tries to force L. Thompson Lincoln to step down as NYC's Big Man of crime. Will Spider-Man be able to take on this new threat?

Peter Parker struggles to get a date for the Fall Formal, and to figure out a way to pay for it. Meanwhile, the unstoppable Rhino – the latest of the Big Man's creations – has sworn vengeance on Spider-Man. Spidey takes the battle directly to the source of his troubles, the previously invisible hand, who has been secretly conducting his villain-of-the-week attacks.

Peter Parker and Harry Osborn try out for the football team and become a bit obsessed with going for the glory. Flint Marko, newly transformed into the Sandman, is out for glory too -- at the expense of our friendly neighborhood Spider-Man.

While Peter takes on the responsibility of helping Aunt May pay the bills, Montana (one of the Big Man's Enforcers) becomes the stunning Shocker to fulfill his responsibility: eliminating Spider-Man.

Peter Parker and Spider-Man both must learn to own their choices when decisions made by Dr. Curt Connors transform Pete's mentor into the Lizard.

Peter Parker attempts to tutor the popular Liz Allan while Spider-Man tries to stop Electro, who will stop at nothing to find a cure for the accident that made him who he is.

Summer is over for Peter Parker and school's ready to start - both literally and in the real world of crime-fighting - as Spider-Man faces his first real challenge, the Enforcers, and his first real super-villain, Vulture.