A mother from Florida vanishes into the night after celebrating her daughter's first birthday; in their search to find her, the police seek answers from the father of her child.

When a young woman vanishes, detectives zero in on her controlling estranged husband--whose story continually changes in the interrogation room.

fter an 80-year-old woman vanishes, local police and the FBI team up in the pursuit of a suspected serial killer.

The authorities begin to question an apparent suicide because they cannot find a gun next to the body.

The authorities search for the man responsible for abducting three women who vanished from the streets of Cleveland for a full decade, and they unravel details about the kidnappings that grabbed national attention in the United States

At the scene of a chilling triple murder in Northern Maine, detectives recover DNA evidence that suggests an out-of-town visitor may be behind the brutal crime.

Investigators question the mother of a deceased baby and her estranged husband to determine how the child died and ended up in a cardboard box, and as they search for answers, they determine who is responsible for the awful crime.

Ten years after a young mother allegedly abandoned her family, her mother-in-law reveals a shocking secret: she believes both of her daughter-in-law's lovers murdered her.

When an 85-year-old man passes away after years of failing health, authorities quickly rule it a natural death and close the case. But years later, a bombshell recording reveals that those closest to him may have played a hand in his passing. Can detectives bring dark family secrets to light in the interrogation room?

When an otherwise healthy young woman is admitted to the hospital with sudden organ failure, an anonymous tip leads authorities to investigate a pattern of unexplained deaths in her family and a shocking prime suspect.

Just after sunrise, investigators respond to a local hospital where an elderly woman is fighting for her life after a brutal six hour assault in her home. Though bruised from head to toe, the victim is able to describe the vicious assault by an unknown intruder in the middle of the night. Quick detective work points the officers to a suspect, but once in the interrogation room, he stonewalls detectives. As evidence starts to mount against the suspect, the victim's health takes a turn for the worse. Can investigators get the suspect to confess and get justice for the elderly victim before it's too late?

In 2012, 26-year-old Timothy "Rambo" Ramsey is killed in a drive-by shooting, but the investigation yields little evidence, and the case goes cold for six years. When detectives re-examine the evidence, they uncover a violent feud between two men...and one of those men may have pulled the trigger in the drive-by shooting. Can detectives get a confession and finally get closure for the family?

A serial killer faces tough questions in the interrogation room after finally being apprehended following decades spent on the run, and three suspects begin to cast blame after a woman's body is found in the middle of the road.

After a successful businessman is brutally strangled, investigators become suspicious of his widow and her secret friend.

After 22 years, a local news story reignites a decades-old cold case, leading investigators to question a close-knit circle of friends who they believe are hiding the truth about the disappearance of a 25-year-old man. Can investigators convince the group of friends to reveal who the killer is and finally get justice for the victim?

A series of random nighttime shootings has the city of Phoenix on edge as police try to end the reign of terror and interrogate two suspects.

After the dismembered remains of a missing woman are found in a freezer, investigators uncover a love triangle and a murderous conspiracy to conceal the truth.

Investigators search for the mystery killer after a man and woman are found shot on the side of the highway, and they find a break in the case when a deputy comes across the victim's missing car filled with guns and silencers.

When a 70-year-old grandmother passes away suspiciously on a road trip, investigators uncover a sinister murder plot while searching for her remains.

Investigators look into a tragic first date after a 25-year-old college student vanishes on Christmas Eve, and they search for answers as to what went wrong.

The search for a missing priest leads detectives on a multi-state manhunt for a suspect who may be the only person with the answers to his whereabouts.