This week on "Face the Nation," with the world still battling COVID's Delta surge, preparations are now underway to combat a new threat.

This week on "Face the Nation" with Margaret Brennan, countries are racing to contain a new COVID strain, and the U.S. is on high alert as experts warn it's likely already here.

This week on "Face the Nation" with Margaret Brennan, we'll check in on the challenges facing America as we prepare to count our blessings this Thanksgiving.

This week on "Face the Nation" with Margaret Brennan, 20 months into the pandemic, we'll sort out the conflicting signals on COVID — and the COVID economy.

Today on "Face the Nation," President Biden ended a rough week with a big win. Will it be enough to end the perception that Democrats can't get anything accomplished?

This week on "Face the Nation" with Margaret Brennan, we begin a week that President Biden said will determine the course of his presidency, and whether Democrats maintain control of Congress.

This week on "Face the Nation" with Margaret Brennan, President Biden's massive spending plan nears the finish line as we inch toward the next leg of the marathon to vaccinate vulnerable Americans.

This week on "Face the Nation" with Margaret Brennan, the challenges facing America continue to grow as Washington's window of opportunity to make bold changes continues to shrink.

This week on "Face the Nation" with Margaret Brennan, the standoff between Democrats on Capitol Hill continues, and our COVID-19 death toll reaches a grim new milestone.

This week on "Face the Nation" with Margaret Brennan, confusion plagues the COVID-19 booster rollout and challenges continue to hobble the Biden presidency.

This week on "Face the Nation" with Margaret Brennan, the Biden administration's booster shot plans hit a roadblock and Congress gets set for a fall budget showdown.

This Week on "Face the Nation with Margaret Brennan," as America remembers the September 11 attacks, 20 years later, presidents past and present urge a divided America to unite. President Biden is trying to force the hesitant to get their vaccine. Will it persuade or just be another political flashpoint?

This week on "Face the Nation," this Labor Day weekend, Americans may be more than willing to turn the page on what's been a sobering summer.

Today on "Face the Nation," a trifecta of catastrophes faces the country and President Biden.

This week on Face the Nation, the perilous evacuation of Americans from Afghanistan continues and the ensuing chaos puts the Biden administration on defense.

This week on "Face the Nation," COVID-19 pushes hospitals in some states to the brink, and overseas, the Taliban offensive in Afghanistan enters a perilous new phase.

This week on "Face the Nation," as the Delta variant marches through the U.S., tempers flash over whether or not to mandate vaccines and masks.

This week on "Face the Nation," U.S. health officials say the war against COVID-19 has changed and the U.S. is back at the #1 spot of the highest number of new infections around the world.

This week on "Face the Nation," COVID's summer surge threatens America's recovery and brings fresh urgency to the country's vaccination push.

This week on "Face the Nation," what will change the minds of the biggest holdouts when it comes to getting vaccinated?

This week on "Face the Nation," warning signs about new coronavirus cases, extreme weather affecting tens of millions and a threat to Russia following the latest cyberattack.

This week on "Face the Nation," Americans are celebrating their freedom, but it is too soon to declare independence from COVID-19?

This week on "Face the Nation," hopes for finding survivors in the collapsed Surfside, Florida, condo building are dim, and a picture of what caused the disaster starts to emerge.

This week on "Face the Nation," back from his trip abroad, President Biden returns home to face familiar problems.

This week on "Face the Nation," America returns to the world stage with President Biden's first trip overseas.

This week on "Face the Nation," challenges for the Biden administration continue as the country struggles to meet the president's self-imposed deadlines.

This week on "Face the Nation," turning the page to another chapter in the COVID saga as spring turns into summer.

This week on "Face the Nation," will the fragile ceasefire in the Middle East continue to hold? Plus, more hopeful signs that we're reaching the end of the pandemic.

This week on "Face the Nation," we'll bring you two big interviews — Israeli Prime Minister Benjamin Netanyahu on the deadliest fighting in the Middle East in years, plus Dr. Anthony Fauci.

This week on "Face the Nation," a surprisingly weak jobs report makes it clear: we're still digging our economy out of the deep hole created by COVID-19.

This week on "Face the Nation," we talk exclusively with two key players in the drama that's likely to impact every American.

This week on "Face the Nation," police reformers press their case — has their mission found its moment?

This week on "Face the Nation," America is facing familiar challenges — with increasing frustration.

Today on "Face the Nation," along with a sunny economic outlook come clouds of caution with the growing number of new coronavirus cases.

Today on "Face the Nation," the COVID pandemic amplifies inequality in America. It's powerful, pervasive, and growing — so what can be done?

Today on "Face the Nation," as President Biden prepares to unveil the next phase of his economic agenda, the continuing threat of COVID and a growing crisis at the border may complicate his plan.

Today on "Face the Nation," familiar crises challenge the country — and the Biden administration.

Today on "Face the Nation," with more access to vaccines and more money headed to people who need it most, there is also concern about Americans moving too quickly to get back to normal.

Today on "Face the Nation," the month of March brings new hope, but also new warnings not to go too far, too fast when it comes to lifting restrictions due to the coronavirus.

This week on "Face the Nation," the U.S. hits two devastating benchmarks — half a million dead and one year since the first reported coronavirus death — but there is hope on the horizon.

This week on "Face the Nation," turmoil in Texas, and President Biden makes his international debut, digging in on the challenges affecting the U.S. around the world.

This week on "Face the Nation," the Senate impeachment trial of the former president charged with inciting insurrection ended exactly as predicted.

This week on "Face the Nation," it's Super Bowl Sunday — we'll look at the efforts to keep it from becoming super spreader Sunday. Plus, we'll have more of CBS News' exclusive interview with President Biden.

This week on "Face the Nation," the nation's capital is an armed fortress as America anxiously awaits the next 72 hours.

This week on "Face the Nation," Washington is still reeling from Wednesday's deadly siege at the Capitol and America is on edge as the clock ticks down the last days of the Trump administration.

The government's plan to vaccine Americans is already showing signs of strain as the number of coronavirus cases and deaths climbs higher than ever, and concern over a new variant of the virus grows.

This week on "Face the Nation," President Biden takes office and is immediately faced with overwhelming challenges. His first priority: COVID-19.