Professor Alice Roberts delves into the life and death of Anne, Queen of England from 1702 to 1714. Being the last Stuart monarch and getting pregnant at least 17 times. Despite her remarkable fecundity, Queen Anne was not able to produce an heir as most of her pregnancies resulted in miscarriages or stillbirths and none of the live births survived beyond childhood. She suffered from gout for much of her life - so much so, that she even had to be carried to her coronation at Westminster Abbey. The gout rendered her largely immobile in her latter years

Professor Alice Roberts revisits the death of Henry IV, best known for usurping and murdering his cousin Richard II. Henry IV suffered from a mysterious debilitating skin condition during the later years of his reign.

Professor Alice Roberts revisits the death of Mary I, also known as Bloody Mary. She was the daughter of Henry VIII and Catherine of Aragon, who experienced phantom pregnancies in her desperation for a child and heir. Forensic pathologist Dr Brett Lockyer helps paint in the detail.

Alice Roberts and Home Office pathologist Brett Lockyer examine the cause of death of George IV, a famously overweight monarch, who enjoyed drinking, partying and spending money.