Shortly after the death of his father Martin and the end of his nearly 20-year relationship with Charlotte, Dr. Frasier Crane has returned to Boston. Hoping for a better relationship with his son, Frederick, now a Boston firefighter, Frasier takes a professorship at Harvard University and moves into Freddy's apartment building. With the help of his family and his new colleagues, Frasier is about to embark on his "third act".