Frasier's sophomore season will see Dr. Frasier Crane return to his radio roots at KACL in Seattle for an episode. The episode will feature previously announced guest stars stepping back into their roles from the original Frasier including Dan Butler as Bob "Bulldog" Briscoe, Edward Hibbert as Gil Chesterton and Harriet Sansom Harris as Frasier's delightfully devilish agent, Bebe Glazer.

Shortly after the death of his father Martin and the end of his nearly 20-year relationship with Charlotte, Dr. Frasier Crane has returned to Boston. Hoping for a better relationship with his son, Frederick, now a Boston firefighter, Frasier takes a professorship at Harvard University and moves into Freddy's apartment building. With the help of his family and his new colleagues, Frasier is about to embark on his "third act".