Frank Black's private and professional lives clash when his sister-in-law is abducted by a convicted sex offender at her child's baptism. Although Bletcher orders him to stay out of the investigation because he is too close to the case, he cannot help but become involved. However, even his extraordinary abilities might not be enough to find his brother's wife.

Frank suffers from memory loss after participating in a mysterious clinical drug trial that resulted in at least one death. Frank is forced to remember what happened as he slowly begins to piece it together in his mind.