Frank is asked to develop a psychological profile on a sheriff who confessed to murdering his entire family. Frank begins to think the story does not add up and finds some inconsistencies in the case.

Frank investigates when he is called in by the Millennium Group to assist them in tracking down an escaped serial killer that Frank helped put behind bars years ago. The killer, Dr. Ephraim Fabricant, was abducted from a hospital while donating a kidney to his dying sister. But during the search, Frank comes face-to-face with an even more terrifying enemy which terrorizes his family.