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Watson runs into an old friend of Sherlock Holmes when her son Angus is admitted to UHOP for temporary paralysis; the fellows help Watson after he grows fond of Angus, pursuing various leads to find a cure to his illness.
While Watson and the team help a woman whose memory resets every three minutes, Watson struggles with auditory hallucinations and questions whether someone is behind his current decline; Moriarty plots his next move.
Ingrid's lies come back to haunt her when her sister Gigi needs to be treated by the team after she develops side effects to the secret treatments Ingrid put her through; Watson and Mary bond over a tragedy.
A year after the death of his friend and partner Sherlock Holmes, Dr. John Watson resumes his medical career as the head of a clinic dedicated to the treatment of rare diseases. However, he soon finds that his old life is not done with him.