Watson runs into brilliant con artist and an old friend of Sherlock Holmes, Irene Adler, when her son Angus is admitted to UHOP for temporary paralysis. The fellows help Watson after he grows fond of Angus and pursue various leads to find a cure to his illness.

Watson is thrown into a detective case when he is unsure whether the patient he is treating for one of the most rare ailments in the world, alien hand syndrome, is guilty of pushing his brother in front of a bus to his death.