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Watson is thrown into a detective case when he is unsure whether the patient he is treating for one of the most rare ailments in the world, alien hand syndrome, is guilty of pushing his brother in front of a bus to his death.
Ingrid's lies come back to haunt her when her sister Gigi needs to be treated by the team after she develops side effects to the secret treatments Ingrid put her through. Also, Watson and Mary bond over a tragedy.
Watson confronts a traumatic event from his Army days that still weighs heavily on him when his Army veteran friend's wife reaches out begging for help when her husband is seemingly having a psychotic break. Meanwhile, Shinwell is asked for one last favor by Moriarty.
A year after the death of his friend and partner Sherlock Holmes, Dr. John Watson resumes his medical career as the head of a clinic dedicated to the treatment of rare diseases. However, he soon finds that his old life is not done with him.