The Fantastic Four stops the Skrulls once again, but Sue ends up in a coma and her dad is framed. The Skurlls also send Super-Skrull again, this time masked as Sue. Meanwhile, Skrull warlord Morrat tries to take over the Skrull empire.

The Fantastic Four help Black Bolt save his people - the Inhumans - who live imprisoned under an unbreakable dome guarded by a simple, but relentless robotic sentry, who misunderstood his orders to protect the Inhumans forever.