The Scorpion escapes from prison, wanting revenge against Spider-Man and J. Jonah Jameson. When he breaks into Dr. Stillwell's lab to find a way to increase his power, the Scorpion drinks a formula that turns him into a giant and sends him on a rampage across the city.

The Human Flies are put on parole and continue a string of thefts across the city, all while framing Spider-Man for their crimes.

Under the guidance of Dr. Noah Boddy, the Green Goblin, Electro, and the Vulture join forces for revenge on Spiderman. In a confrontation with Noah Boddy's three stooges, Spidey practices ventriloquism to cause each of the three miscreants to think that he is being insulted by the others, and the excitable trio of villains begin fighting each other. 

Art robberies are committed by an old enemy of Spiderman, actor Charles Cameo, who can utilize masks and make-up to usurp any identity, including those of J. Jonah Jameson and Spiderman!

Dr. Curtis Conner goes missing in the Florida swamps after finding the Fountain of Youth. When Spidey investigates the scientist's disappearance, he discovers a fifteenth century Spanish conquistador, Ponce de Leon, who is intent upon keeping the magical fountain a secret. 

Because he hates rock-and-roll for its having replaced classical music in the tastes of the masses, a fiddler with a deadly, sonic violin seeks revenge upon pop-music sponsor Cyrus Flintridge.

Doctor Octopus steals a device made to nullify missiles and Spider-Man must bring him to justice before he can use it for his own nefarious purposes.

The Green Goblin uses the magic spells of Blackwell the Magician to commit a series of thefts across the city, and Spider-Man vows to put a stop to the Goblin's magical heists.

The nefarious Vulture traps Jameson inside of a tower-clock and uses the well-informed Daily Bugle publisher as a source of information on the whereabouts of a visiting diamond merchant and the testing of military equipment- two prospective heists for the greedy bird-man.

Life-like and substantial shadows of beasts are projected in various locations in New York City by the Phantom's new Shadow-Scope glasses to cause panic and enable the Phantom to effect unconstrained bank and jewelry store robberies.

Spidey chases the culprit in an attempted theft of jewels from a countess and is surprised to find that his opponent, dressed in a black "Human Fly" costume, also has the ability to scale walls and can cross thin wires between buildings. 

Oil is being stolen in huge quantities by Dr. Von Schlick, a chemist villain garbed in a rubber, non-stick suit and armed with petroleum-based bubbles that he fires from his fingers to envelope Spidey.

Spiderman's old enemy, the rampaging Rhino, is stealing gold bullion to mold an auric likeness of himself. 

A bald-headed mastermind named the Plotter employs two ridiculous criminals, Cowboy and Ox, to steal a blueprint to a missile.

Reports of a legendary, flying ghost ship, the Flying Dutchman, being sighted near Smuggler's Cove summon Spidey to the area, where his investigation into the phantom ship's appearance leads him to a cave in which he finds his sworn adversary, Mysterio, plotting with a pair of thugs. 

When a Jekyll-and-Hyde poster comes to life at the soon-to-be-demolished Castle Theatre, Spidey visits the theatre and encounters a mischievous Blackwell the Magician, who is trying to attract public attention to the theatre in hope of preventing its demolition

A scientist, Dr. Noah Boddy, renders himself invisible by means of a machine, then acts to avenge himself upon Jameson, who publically maligned his theory of invisibility. 

Spiderman battles an Arabian jewel thief, whose magical flute induces animals into attacking Spidey.

Historic villains Blackbeard the Pirate, Jesse James, and the Executioner of Paris are committing robberies in New York City, and Spidey tracks them to their lair- Parafino's Wax Museum, where Spidey's wax-master enemy is scheming to besiege and plunder the city with robotized wax villains. 

Miss Trubble, a book dealer obsessed with mythology, is owner of a magical chest from which she summons a succession of mythological figures, from centaurs to the Cyclops to Diana the Hunter-Goddess, to commit robberies of ancient artifacts on her behalf.

After being shunned yet again by the Science Hall of Fame, potential nominee Dr. Magneto decides to use his knowledge and mastery of magnetism against the world but finds Spider-Man stands in the way. 

When Peter Parker and the rest of the press are denied access to the visiting Prime Minister of Rutania, Parker decides to sneak into the embassy as Spider-Man. There he stumbles across an evil imposter who's assumed the Prime Minister's identity so he can steal the 20 million dollars of charity money promised to the country of Rutania for himself.

J. Jonah Jameson receives an anonymous gift from an "unknown admirer". The gift it turns out is an unusual, hypnotic idol which entrances Jameson with a light beam, hypnotizing him enough to be open to the suggestion of putting money inside the idol's head at the request of this "admirer", one R. E. Cliventon. The money is then collected by Cliventon's Aborigine servant only on this occasion Spider-Man catches them in the act. 

Knowing his thieving ways, Spider-Man lays a trap for the Fifth Avenue Phantom when he places a spider-tracer on a fur coat at Benet's department store. What he runs into instead is trouble in the form of the Phantom's female robot slaves, cunningly placed on display in department stores as shop-window mannequins. Can Spider-Man discover the Phantom's secret and put an end to his crime spree?

When Peter Parker has a cold, he must try to stop the Rhino from stealing specific items for a device.

Electro escapes from prison and Spider-Man must catch him. 

An escaped prisoner hides out in Parafino's Wax Museum and Spider-Man must enter the Wax Museum and deal with Parafino.

Spider-Man must stop a giant Car-Eating Robot from destroying Manhatten. 

The Green Goblin hypnotizes J. Jonah Jameson and plans to use him as a Medium for the Spirit World in order for the Green Goblin to summon ghosts to his aid. Can Spider-Man foil the Green Goblin's plot?

J. Jonah Jameson commissions the creation of the Scorpion to hunt down Spider-Man, but gets more than he bargained for when the Scorpion turns his sights on him.

Spider-Man is framed for the theft of the Goliath Diamond and must track down the real criminal, the shape-shifting Sandman.

The Vulture takes over the skies with his army of birds and demands a two million dollar ransom in return.

Spider-Man is pursued by a robot controlled by J. Jonah Jameson, who will stop at nothing until he finally captures him once and for all.

When Spider-Man is framed for a robbery, the master illusionist Mysterio makes an offer to take the wall-crawler out for J. Jonah Jameson. With his name tarnished, Spider-Man must find a way to prove his innocence and stop Mysterio.

Spider-Man travels to Florida to discover the mystery behind the mysterious Lizard Man roaming the Everglades.

Spider-Man is on the run from the police after J. Jonah Jameson accuses him of a robbery committed by the shocking supervillain Electro.

Reports of strange lights in the wood leads Peter Parker and Betty Brant to investigate. Turns out Doc Ock has a secret laboratory in a cave.

It's a really hot day but Doctor Smartyr notices ice forming everywhere. It turns out there's an alien race called the Plutonians in town.