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A woman whom Jess once loved arrives on a stagecoach, and asks Jess to help her run away from her husband and get to Mexico.
Gun-for-hire Ed Caulder arrives in Laramie, waiting for a letter that will reveal his next target. When his leg is injured in a cougar trap, he's rescued by Slim and Andy, and stays at the Sherman ranch while he heals. Based on his checkered past, Jess thinks he may be the person Caulder is there to kill.
Jess' brother-in-law has deserted the Army and shows up at the ranch looking for his help getting to Canada.
When a woman shoots the son of Chief, all of the stagecoach passengers must remain at the Sherman ranch and defend themselves as best they can. One of the passengers is a disgraced former Army Major who was court martialed and made to resign for an offense he didn't commit.
Evangelist Essie Bright stops in Laramie, after acquiring an admirer along the way.
Drifter Jess Harper arrives at the Sherman ranch and relay station, owned by Slim Sherman and his 12-year-old brother Andy. Soon they and their hired hand, Jonesy, are held captive by an outlaw and his gang, trying to kidnap a Judge and rescue one of their gang. After it's resolved, will Jess drift on, or stay at the Sherman ranch?