The hunters venture into the Everglades Triangle, an area known for mysterious disappearances and swarms of snakes; Troy, Chase and Bill use a drone to search the swamp from the air, while Bruce and Zak track snakes with a handheld thermal device.

Troy, Chase, and Bill gamble on a long journey into the center of the Everglades, following the migration of giant pythons to the furthest depths of the wetlands. Meanwhile, Bruce and Zak head deep into outlaw country, looking for snakes hiding on a deserted bootlegging trail...but what they uncover is far more shocking than they expected.