On his first day back at Bronx General, Wolf treats an ex-con who has a medical emergency during a hostage situation. Ericka and Charlie care for a newborn baby in the midst of a life-threatening illness.

Wolf and Josh's relationship is tested when they tackle a case that hits close to home. Carol and Thorne deal with a patient harboring a huge secret. Van returns and helps Ericka and Dana through their own personal crises.