Having the same stylistic tone as the first season, Closer to You 2 follows Han Fei as she time travels to her university days and reunites with her boyfriend Wu Jing Hao who was supposed to be lying unconscious in a hospital bed. They continue their love story while trying to solve the mysteries of fate. Ten years ago, Wu Jing Hao fell into a coma to save Han Fei; and she has been waiting for him to wake up ever since. By chance, the 28-year-old Han Fei travels back in time to the commencement ceremony at the university campus. If things were as it once was, Wu Jing Hao should've been in the hospital. Instead, Wu Jing Hao has lost part of his memories. Han Fei's mind is burning with questions yet she walks into Wu Jing Hao's life once again to continue their romance. In the process, she discovers that there is no escape from fate.

A handsome surgeon tries to make up for his biggest regret. When he earns the chance to go back in time to his senior year of high school, he strives to overcome his cowardice to help his classmate Han Fei and prevent an impending tragedy.