The presenter experiences the Canyon via helicopter, kayak and steam train. He explores the region's history and towns such as Williams, Arizona, on the iconic Route 66, which earns its living from tourism, with 1950s diners and cowboy-themed bars receiving five million visitors a year.

Nick exchanges gifts with the Hualapai tribe whose ancestors used to roam the Canyon, explores the caves 21 storeys below the surface, and takes part in a project to restore the region's endangered condor population.