Dan Jones reveals why Londoners were desperate to stop the fire reach the Tower, Rob Bell looks at the bizarre 17-century methods of treating burns and Suzannah Lipscomb examines a controversial new theory about how many people died. They also examine how the authorities dealt with the 100,000 people who had lost everything and how a new city was built from the ashes.

Dan Jones follows the path of the fire on the worst day of its rampage as it swept through some of London's iconic buildings. Suzannah Lipscomb finds evidence in the archives of who was blamed and who escaped scot free. Rob Bell visits Imperial College London for more information about the spread of the fire and to re-create the intense heat it generated.

Dan Jones visits the exact location of the bakery where it started, Suzannah Lipscomb reveals how Londoners tried to save their belongings, and Rob Bell investigates 17th-century building materials and the prevailing weather conditions.