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Mac and Jack head down to Louisiana to capture a fixer who can deliver the goods on his boss. However, a family of bounty hunters--the Coltons--get to him first.
When Matty's goddaughter Vanessa is shot to death, the team discovers that the MO matches that of San Francisco's Zodiac Killer... who was never caught.
Matty sends the team to Amsterdam on a supposedly easy surveillance run: so easy that she sends Wilt with them on his first field mission. However, things go south when someone frames the team for a terrorist bombing.
Angus "Mac" MacGyver, creates the Department of External Services (DXS), a clandestine organization within the U.S. government where he uses his extraordinary talent for unconventional problem-solving and vast scientific knowledge to save lives.