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When Matty's goddaughter Vanessa is shot to death, the team discovers that the MO matches that of San Francisco's Zodiac Killer... who was never caught.
Matty sends Jack and Mac to Atlanta to track down a Most Wanted fugitive who apparently has a mole in the FBI working for him. When the two men get there, they discover that the truth isn't what they were told and soon find themselves on the run. Meanwhile, Matty holds performance reviews with her new team.
Mac and Jack head down to Louisiana to capture a fixer who can deliver the goods on his boss. However, a family of bounty hunters--the Coltons--get to him first.
Angus "Mac" MacGyver, creates the Department of External Services (DXS), a clandestine organization within the U.S. government where he uses his extraordinary talent for unconventional problem-solving and vast scientific knowledge to save lives.