FAMILY GUY takes viewers behind the scenes of a regular FAMILY GUY production week, with James Woods as the guide. See the ins-and-outs of what goes into the making of a FAMILY GUY episode and watch the drama unfold as Peter is replaced and ends up in the office of Fox Television Group Chairmen and CEOs Dana Walden and Gary Newman to pitch his very own new series.

In order to "save" Stewie from autism, Peter and Lois decide not to vaccinate him and then proceed to convince the rest of Quahog to follow suit. Stewie runs away to save himself from diseases until Sean Penn (guest-voicing as himself) swoops in to save the day and brings vaccines to the whole town.