In the 5th season finale, Larry discovers who his real parents are, and flies to Arizona to meet them. After a life-changing religious revelation, Larry decides to give Richard Lewis his kidney. Will Larry survive the operation... or is it the end?

Larry takes his chances with a Korean Bookie. While Cheryl's friends get married on the beach, Larry accuses the Korean Bookie of cooking up Jeff's dog and serving him for dinner.

Larry's quest to get Richard Lewis a kidney takes a turn when Larry learns about the head of the kidney consortium. After befriending the guy, Larry invites him and his daughter on a ski trip. Like everything Larry does, the trip ends as badly as it started.

A sex offender (Rob Corddry) moves into the neighborhood, and becomes friends with Larry. Larry also suspects that Dr. Mark is stealing his newspaper, after his neighbor Ethel claims she saw him take it. Tension mounts when all of these people are guests at Larry's Passover Seder.

Larry joins the "Make A Wish" foundation, and swaps his smoking jacket with Hugh Hefner.

Larry learns that Richard Lewis is bedridden and needs a kidney transplant. Larry and Jeff both turn up as positive matches for Lewis, but neither one are willing to give up their precious organs that easily.

Larry offends a Japanese art dealer by implying that his father was not a real Kamikaze pilot. Later, Larry accuses his own dad's retirement home of fixing their bingo game.

Larry goes bra-shopping for his maid, landing him in trouble with her husband and his neighbors.

Wanda Sykes thinks Larry purposefully adopted a dog she deems "racist", Larry falls off his pedestal as a friend of the lesbian community, and Larry hires a private investigator to uncover some information about his past.

Larry is changed by a near-death experience, a revelation about his father, and a sandwich named after him.