María's mother dies and is veiled at home. Alex Berger goes to the doctor and is diagnosed with lung cancer and this causes Alex's death. In addition to this loss, María goes through another pain, when she learns of the death of her son Enrique.

Jorge decides to hide his illness from María until his health worsens and he dies. María goes to the consolation of her friend Frida and she decides to give her a portrait made by herself. Alex Berger confesses his love to Maria and proposes to her.

Enrique doesn't answer his mother's calls or letters, so María decides to go visit him. Maria tries to help her personal assistant in an emergency, without imagining what she will find. Jorge Negrete does the impossible to conquer María.

After an accident, María decides to marry Agustín Lara. The actress lands the leading role in a film by Emilio "El Indio" Fernández without knowing that she might regret her decision. María finds Agustín with another woman in her bed.

María stars in the film that gives her the nickname "La Doña". Agustín Lara conquers María and they have a passionate relationship. Her father apologizes to her for rejecting her. María takes advantage of her fame to organize a plan and get her son back.

María stars in a film that gives her category and recognition as an actress. Despite family rejection and being humiliated on set, María does not stop, on the contrary, she is motivated to show that her destiny is to be an icon of Mexican cinema.

María meets Enrique and they fall in love, so he decides to ask Bernardo for her hand. María's father does not agree with his daughter marrying a man older than her. María manages to marry Enrique, not knowing that her life will not be perfect.

María and her brother have a good relationship, but their parents fear that their love will exceed the limits, so without thinking about the consequences, Bernardo makes a difficult decision.