No. 19 USC (8-3) hosting UCLA (3-8) in a crosstown battle from the Los Angeles Memorial Coliseum in Los Angeles, Calif.

Longtime conference foes, USC and UCLA shared the L.A. Coliseum from 1929 to 1981. USC leads the all-time series, 51-34-7, and won last year's matchup, 19-13.

Live from The Rose Bowl in Pasadena, California.

Live from West Shore Home Field at Beaver Stadium in University Park, Pennsylvania.

The Associated Press-ranked No. 1 Ohio State Buckeyes (9-0) host the UCLA Bruins (3-6) from Ohio Stadium in Columbus, Ohio.

This will be the first matchup between UCLA and Ohio State since Sept. 22, 2001, when the Bruins defeated the Buckeyes, 13-6, at the Rose Bowl. This will also be the first matchup between the two teams at Ohio Stadium since 1999, which the Buckeyes won, 42-20.

USC (5-2, 3-1 Big Ten) at Nebraska (6-2, 3-2). From Memorial Stadium in Lincoln. Matt Rhule's Cornhuskers dress up in all-black alternate uniforms in looking to contain the top-ranked USC offense (530 ypg) piloted by QB Jayden Maiva. The UNLV transfer threw 3 TDs and ran for the clincher in last year's 28-20 win, upping the Trojans' all-time series edge on Nebraska to 5-0-1.

The Associated Press-ranked No. 25 Michigan Wolverines (5-2) visit the Michigan State Spartans (3-4) in a historic rivalry matchup for the Paul Bunyan Trophy.

 No. 25 Michigan visits in-state rival Michigan State at Spartan Stadium in East Lansing, Mich., In a rivalry dating to 1898, Michigan leads the all-time series 74-38-5, having won three consecutive matchups.

Live from Notre Dame Stadium in Notre Dame, Indiana.

The Associated Press-ranked No. 13 Notre Dame Fighting Irish (4-2) host the No. 20 USC Trojans (5-1) in a historic rivalry matchup with College Football Playoff implications, this Saturday, Oct.

In a rivalry dating back to 1926, Notre Dame leads the all-time series against the Trojans, 52-38-5, having won six of the previous seven matchups.

No. 15 Michigan visits USC at the Los Angeles Memorial Coliseum in Los Angeles, Calif.

Defending national champion and No. 1 Ohio State hosts Minnesota at Ohio Stadium in Columbus, Ohio. 

Live from Beaver Stadium on the campus of Pennsylvania State University in Pennsylvania State University.

Live from Memorial Stadium in Bloomington, Indiana.

Saturday's game will mark just the second ranked matchup in series history, with the only prior meeting 75 years ago (No. 12 Illinois defeated No. 19 Indiana, 20-0, on Oct. 28, 1950).

Live from Notre Dame Stadium in Notre Dame, Indiana.

Live from Spartan Stadium in East Lansing, Michigan. The Michigan State Spartans host the Boston College Eagles in primetime. 

Live from Michigan Stadium, aka "the Big House," in Ann Arbor, Michigan.