On their last show of 2016, Desus & Mero celebrate the holidays by braving the cold and bros of Santacon.

Desus & Mero watch videos that make them never want to book Delta flights to Kentucky. Angie Martinez stops by to try her best to make the guys cry.

Desus & Mero shoutout the security guard who was way too excited to see the San Diego Chargers Cheerleaders. John Hodgman sits down to talk about the time he kinda wished he and his wife had gotten hit by a car and to throw some shade at the Verizon guy.

Desus compliments Mero for his "butt expertise." Garbage Time's Katie Nolan stops by to audition for the newly open position in Fifth Harmony.

Mero pleads with Chrissy Teigen to follow him on Twitter again while Desus loses his shit. Comedian Franchesca Ramsey tells us why you should never make white girls cry.

Desus and Mero debate whether or not you should mouth kiss your kids. Willie Geist stops by to talk about interviewing Mick Jagger.

Desus & Mero discuss Kanye's strangest move to date: meeting with Trump. Nick Cannon stops by to dish on why he wasn't invited to his kids' playdate with Beyonce.

Desus & Mero join Trump in questioning his intelligence. Immortal Technique sits down to talk about that time he made Lin-Manuel Miranda sing in a garbage can.

Desus watches Mero destroy the Apple Crush challenge. ESPN's Pablo Torre stops by to name drop Mark Zuckerberg's wife and to teach us the New York way to kill a mouse.

Desus & Mero make plans to spend Mother's Day with Derek Jeter. Legendary hip hop group The Lox stop by to talk about coming up and staying there.

Desus & Mero take credit for Klay Thompson's 60 point explosion. Knicks Superfan The Loopy Blogger stops by to talk about who he has beefs with and why he's a Dallas Cowboys fan.

The Bronx's own Desus Nice and The Kid Mero, aka the Bodega Boys, give their takes on politics, sports, entertainment and other subjects they don't really know about.

Desus & Mero discuss Melo's last second shot and Obama's last minute weed endorsement. Model Amina Blue stops by to talk about music video life.

Desus & Mero discuss what Mitt Romney ate besides his pride during dinner with Donald Trump. Chris Hayes stops by to talk growing up in the Bronx.

Desus & Mero discuss Colin Kaepernick's foray into controversial t-shirt wearing. Artist Tony Peralta stops by to talk Washington Heights gentrification.

Desus & Mero celebrate Thanksgiving by giving thanks for their favorite moments from past episodes of Desus & Mero.

Desus & Mero prepare for Thanksgiving with blogger @KFC from Barstool Sports.

Desus & Mero say some problematic $#!%. Columnist Michael Arceneaux joins them.

Desus & Mero salute the alt-right for not being as bad as actual Nazis and impersonate DMX. Special guest Rashida Jones stops by to show us her monkey bite scar.

Desus & Mero break down Kanye's breakdown and shout out yoga goats. NY Times Food editor Sam Sifton stops by to talk about chopped cheese appropriations.

Desus & Mero discuss Drake's staged crush. Cord Jefferson stops by to play a game of where in the world was Cord Jefferson.

Desus & Mero look forward to Trump's reality show presidency. Adult film star Janice Griffin stops by to talk racism in porn and adult stocking stuffers.

Desus & Mero discuss Barry's dig on Hillary and New Balance's unwanted endorsement deal. Nick Catchdubs stops by to talk about 50 Cents' rainmaking skills.

Desus & Mero welcome white nationalism to the White House and listen to Yoko Ono's screaming tribute to President-elect Trump. Bomani Jones stops by to discuss The Root 100 list.

Desus & Mero talk the awkward Trump/Obama meet and greet, the awful Paul McCartney Mannequin Challenge and Mero's wife surprises him with a phone call.

Desus & Mero nurse their election hangover by continuing to talk about the election. DeRay McKesson stops by to talk election aftermath and his activism.

Desus & Mero usher in the end of our national nightmare live! With special in-studio guests Talib Kweli, Cardi B and Jim Jones. Plus political commentary from Joe Budden, Ezra Koenig, Charlamagne Tha God and The Fat Jew.

Desus & Mero endorse Jay Z's endorsement of Hillary and Putin's love of bears. Former White House Deputy Chief of Staff Alyssa Mastromonaco stops by to talk about what life with Barry is like.

Desus & Mero discuss the World Champion Chicago Cubs' disgusting dugout celebration, Kenny Chesney's disgusting snub of Beyonce and Johnny Damon's disgusting support of Trump.

Desus & Mero beg their fans to stop tweeting that the Knicks suck. Rembert Browne stops by to reminisce about his flight on Air Force 1.

Desus & Mero judge Lebron's Halloween party and Jay and Bey's costumes. But the scariest part of last night was Tump leading the polls by one point.

Desus & Mero welcome Anthony Weiner back into the headlines and shout out the world's largest pit bull. Jillionaire stops by to question the need for Halloween.

Iman Shumpert drops in to watch clips and give some takes. Trump again reminds us how smart he is. Ty Dolla $ign talks about his new album "Beach House 3."

Amazon wants the key to your house. A dude takes heat for the pics he's liking on Instagram. Talib Kweli talks his new album and his relationships with Chappelle and Kanye.

Bob Corker calls out Trump for all his lies. Ben Carson gets cooked by Rep. Al Green at a HUD budget hearing. Al Harrington talks his new Cannabis film and his NBA days.

Lil B has love for A Boogie's crew after they jump him. Gabrielle Union preaches butt play reciprocity. J.B. Smoove talks "The Book of Leon" and the zombie apocalypse.

Desus & Mero recap the debate lowlights, breakdown Kanye's latest rant and Charlamagne Tha God stops by to watch a clip of the first ever hate crime during a game of cornhole.

Desus and Mero don't talk about the debate but they do talk about a smoking North Korean chimp. DJ Vashtie Kola stops by.

Desus and Mero discuss Mary J Blige's divorce proceedings, Al Green's painful anniversary and shout out conspiracy theorists everywhere.

In the late night premiere, the guys dive into discussing the "rigged" election. Later comedian/rapper Awkwafina stops by the studio.