Comedians James Acaster and Ed Gamble, Strictly dancer Katya Jones, Olympic snowboarder Aimee Fuller, actors Nicola Thorp and Nikesh Patel, mathematician Bobby Seagull, social media star Saffron Barker and TV therapists Nik and Eva Speakman go on the run across mainland UK while an elite team of police and military personnel try to track them down. The hunters being armed with the powers of the state - CCTV and ANPR cameras, drones, dogs, mobile phone tracking and social media publicity campaigns, means the celebrities have to be creative to evade capture. As the competitors escape from Shrewsbury prison and go on the run, the hunters are instantly on their tails, tracking them with CCTV cameras and a helicopter. All in aid of Stand Up To Cancer, James and Ed make a daring move with a six-course tasting menu at a Michelin guide restaurant while Nik and Eva escape on a tandem bike.

James and Ed plot a big surprise for the hunters at Pinewood Studios and Nik and Eva hope a This Morning presenter will help them hide. Katya and Aimee do some extreme sports over in Surrey while Nikesh hides out at the home of a new associate in the Midlands. Saffron and Bobby desperately need a new plan.