Christmas time brings chaos to the hospital. Fitz tends to a patient that had a run in with the cops, while Chen must deal with a patient who was unfaithful in his marriage. Both Chen and Fitz evaluate their own careers and relationships. Ming visits her father, who has unwanted advice in regards to her fertility problems. Sri receives some unsettling news.

Fitz and Chen are put into isolation, after Fitz returns home with a mysterious ailment. Ming undergoes quarantine at home, where she reconsiders their adoption plan.