Cosmo and Wanda are very tired from taking care of Poof, so Timmy volunteers to take over and give them a night on the town. However, the minute they poof away, Timmy loses Poof and must find him before they return.

Timmy needs to go to the hospital to have his tonsils removed, because he has tonsillitis. Unfortunately, his candy striper nurse is Vicky, who is determined to make his stay in the hospital as painful as possible.